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Big Apple Comix is an early independent comic book published by Flo Steinberg in 1975. A historically important link between underground comix and what would later be called alternative comics, it contains 11 sometimes sexually frank stories by such mainstream creators as Neal Adams, Archie Goodwin, Denny O'Neil, Herb Trimpe, Al Williamson, and Wally Wood. Most of its stories revolve around New York City (colloquially known as The Big Apple) during a particularly low ebb in the city's finances, crime situation, race relations, and infrastructure.

The book was among a handful of 1960s-1970s precursors of the independently produced comics that first proliferated with the 1980s rise of "direct market" comic-book stores.

Linda Fite and John Verpoorten handled production work for the comic.

Steinberg printed 20,000 copies. Warren Publishing, for which she ran its mail-order Captain Company division, allowed her to store inventory in the company's storage space.